Knock-Out:Article Title: Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity--An Overview for Applied Toxicology
Article Snippet: .. Experiments with Dicer knockout mice have suggested a critical role of specific miRNAs in orchestrating kidney development and maintaining the functional and structural integrity of the tubular and glomerular barrier. miRNAs with a high abundance within the kidney or which are up regulated after an insult are shown in Table . table ft1 table-wrap mode="anchored" t5 Table VII caption a7 MicroRNAs linked to urinary tract and kidney disease miRNA Function/pathway Targets Ref. Bladder cancer miR-129 Signal transduction/protein expression SOX4 GALNT1 ( 44 ) miR-221 Apoptosis TRAIL pathway ( 83 ) miR-1/133a/218 Cytoskeleton LASP1 ( 84 ) miR-19a Apoptosis/mTOR pathway PTEN ( 85 ) miRs-30a-3p/133a/199a Differentiation KRT7 ( 86 ) miR-34a Cell cycle control CDK6 ( 87 ) miR-99a/100 Proliferation FGFR3 ( 88 , 89 ) miR-101 Gene expression EZH2 ( 90 ) miR-125b Apoptosis/proliferation E2F3 ( 91 ) miRs-145/133a Cytoskeleton FSCN1 ( 84 ) miR-145 Signal transduction CBFB PPP3CA CLINT1 ( 92 ) miR-200/205 EMT ZEB 1 and 2 ( 93 , 94 ) miR-200 family EMT ERRFI-1/EMT process ( 95 ) Renal cancer miR-34a Apoptosis Sirt1 ( 87 ) miR-23b Modulation of TGF-ß1 signaling/ apoptosis and hypoxic signaling POX ( 96 ) OncomiR-1 a (Wilms’ tumor) Proliferation response to E2F3 PTEN ( 97 ) miR-200c EMT SIP1 ( 98 ) ZEB2 miR-141 EMT SIP1 ZEB2 Diabetic nephropathy miR-21 Inhibitor of apoptosis/cell proliferation PTEN ( 99 ) miR-23b Modulation of TGF-ß1 signaling/apoptosis and hypoxic signaling POX ( 96 ) miR-30 family Loss in podocyte specific dicer knockout CTGF Xlim1/Lhx1 ( 100 ) miR-192 Collagen synthesis SIP1, ZEB 1 and 2 ( 101 ) miR-216 Modulation of TGF-ß1 signaling YB-1 PTEN ( 102 ) miR-377 Enhanced expression by high glucose in mesangial cells/synthesis of fibronectin PAK1 SOD1/2 ( 103 ) Polycystic kidney disease miR-17 Promotion of proliferation PKD2 ( 104 ) miR-15a Progression cell cycle Cdc25A ( 105 ) Open in a separate window This list is not intended to be exhaustive. a Synonyme miR 17–92 cluster, miR microRNA, PAK1 p21-activated kinase 1, SIP1 Smad-1 interacting protein, SOD superoxide dismutase, TGF-β1 transforming growth factor beta 1, YB-1 Y-box protein-1, PTEN phosphatase and tensin homologue, mTOR mammalian target of rapamycin, EMT epithelial-to-mesenchymal transition Overview of miRNAs Described in Relation to Renal Diseases and/or Damage (Also Shown are the Reexpected Function and Target mRNAs Identified so Far) The expression profile of miRNAs within the healthy kidney has provided a general idea of miRNA constitutive expression and which miRNA serves a specific functional role. ..
Functional Assay:Article Title: Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity--An Overview for Applied Toxicology
Article Snippet: .. Experiments with Dicer knockout mice have suggested a critical role of specific miRNAs in orchestrating kidney development and maintaining the functional and structural integrity of the tubular and glomerular barrier. miRNAs with a high abundance within the kidney or which are up regulated after an insult are shown in Table . table ft1 table-wrap mode="anchored" t5 Table VII caption a7 MicroRNAs linked to urinary tract and kidney disease miRNA Function/pathway Targets Ref. Bladder cancer miR-129 Signal transduction/protein expression SOX4 GALNT1 ( 44 ) miR-221 Apoptosis TRAIL pathway ( 83 ) miR-1/133a/218 Cytoskeleton LASP1 ( 84 ) miR-19a Apoptosis/mTOR pathway PTEN ( 85 ) miRs-30a-3p/133a/199a Differentiation KRT7 ( 86 ) miR-34a Cell cycle control CDK6 ( 87 ) miR-99a/100 Proliferation FGFR3 ( 88 , 89 ) miR-101 Gene expression EZH2 ( 90 ) miR-125b Apoptosis/proliferation E2F3 ( 91 ) miRs-145/133a Cytoskeleton FSCN1 ( 84 ) miR-145 Signal transduction CBFB PPP3CA CLINT1 ( 92 ) miR-200/205 EMT ZEB 1 and 2 ( 93 , 94 ) miR-200 family EMT ERRFI-1/EMT process ( 95 ) Renal cancer miR-34a Apoptosis Sirt1 ( 87 ) miR-23b Modulation of TGF-ß1 signaling/ apoptosis and hypoxic signaling POX ( 96 ) OncomiR-1 a (Wilms’ tumor) Proliferation response to E2F3 PTEN ( 97 ) miR-200c EMT SIP1 ( 98 ) ZEB2 miR-141 EMT SIP1 ZEB2 Diabetic nephropathy miR-21 Inhibitor of apoptosis/cell proliferation PTEN ( 99 ) miR-23b Modulation of TGF-ß1 signaling/apoptosis and hypoxic signaling POX ( 96 ) miR-30 family Loss in podocyte specific dicer knockout CTGF Xlim1/Lhx1 ( 100 ) miR-192 Collagen synthesis SIP1, ZEB 1 and 2 ( 101 ) miR-216 Modulation of TGF-ß1 signaling YB-1 PTEN ( 102 ) miR-377 Enhanced expression by high glucose in mesangial cells/synthesis of fibronectin PAK1 SOD1/2 ( 103 ) Polycystic kidney disease miR-17 Promotion of proliferation PKD2 ( 104 ) miR-15a Progression cell cycle Cdc25A ( 105 ) Open in a separate window This list is not intended to be exhaustive. a Synonyme miR 17–92 cluster, miR microRNA, PAK1 p21-activated kinase 1, SIP1 Smad-1 interacting protein, SOD superoxide dismutase, TGF-β1 transforming growth factor beta 1, YB-1 Y-box protein-1, PTEN phosphatase and tensin homologue, mTOR mammalian target of rapamycin, EMT epithelial-to-mesenchymal transition Overview of miRNAs Described in Relation to Renal Diseases and/or Damage (Also Shown are the Reexpected Function and Target mRNAs Identified so Far) The expression profile of miRNAs within the healthy kidney has provided a general idea of miRNA constitutive expression and which miRNA serves a specific functional role. ..
Transduction:Article Title: Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity--An Overview for Applied Toxicology
Article Snippet: .. Experiments with Dicer knockout mice have suggested a critical role of specific miRNAs in orchestrating kidney development and maintaining the functional and structural integrity of the tubular and glomerular barrier. miRNAs with a high abundance within the kidney or which are up regulated after an insult are shown in Table . table ft1 table-wrap mode="anchored" t5 Table VII caption a7 MicroRNAs linked to urinary tract and kidney disease miRNA Function/pathway Targets Ref. Bladder cancer miR-129 Signal transduction/protein expression SOX4 GALNT1 ( 44 ) miR-221 Apoptosis TRAIL pathway ( 83 ) miR-1/133a/218 Cytoskeleton LASP1 ( 84 ) miR-19a Apoptosis/mTOR pathway PTEN ( 85 ) miRs-30a-3p/133a/199a Differentiation KRT7 ( 86 ) miR-34a Cell cycle control CDK6 ( 87 ) miR-99a/100 Proliferation FGFR3 ( 88 , 89 ) miR-101 Gene expression EZH2 ( 90 ) miR-125b Apoptosis/proliferation E2F3 ( 91 ) miRs-145/133a Cytoskeleton FSCN1 ( 84 ) miR-145 Signal transduction CBFB PPP3CA CLINT1 ( 92 ) miR-200/205 EMT ZEB 1 and 2 ( 93 , 94 ) miR-200 family EMT ERRFI-1/EMT process ( 95 ) Renal cancer miR-34a Apoptosis Sirt1 ( 87 ) miR-23b Modulation of TGF-ß1 signaling/ apoptosis and hypoxic signaling POX ( 96 ) OncomiR-1 a (Wilms’ tumor) Proliferation response to E2F3 PTEN ( 97 ) miR-200c EMT SIP1 ( 98 ) ZEB2 miR-141 EMT SIP1 ZEB2 Diabetic nephropathy miR-21 Inhibitor of apoptosis/cell proliferation PTEN ( 99 ) miR-23b Modulation of TGF-ß1 signaling/apoptosis and hypoxic signaling POX ( 96 ) miR-30 family Loss in podocyte specific dicer knockout CTGF Xlim1/Lhx1 ( 100 ) miR-192 Collagen synthesis SIP1, ZEB 1 and 2 ( 101 ) miR-216 Modulation of TGF-ß1 signaling YB-1 PTEN ( 102 ) miR-377 Enhanced expression by high glucose in mesangial cells/synthesis of fibronectin PAK1 SOD1/2 ( 103 ) Polycystic kidney disease miR-17 Promotion of proliferation PKD2 ( 104 ) miR-15a Progression cell cycle Cdc25A ( 105 ) Open in a separate window This list is not intended to be exhaustive. a Synonyme miR 17–92 cluster, miR microRNA, PAK1 p21-activated kinase 1, SIP1 Smad-1 interacting protein, SOD superoxide dismutase, TGF-β1 transforming growth factor beta 1, YB-1 Y-box protein-1, PTEN phosphatase and tensin homologue, mTOR mammalian target of rapamycin, EMT epithelial-to-mesenchymal transition Overview of miRNAs Described in Relation to Renal Diseases and/or Damage (Also Shown are the Reexpected Function and Target mRNAs Identified so Far) The expression profile of miRNAs within the healthy kidney has provided a general idea of miRNA constitutive expression and which miRNA serves a specific functional role. ..
Expressing:Article Title: Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity--An Overview for Applied Toxicology
Article Snippet: .. Experiments with Dicer knockout mice have suggested a critical role of specific miRNAs in orchestrating kidney development and maintaining the functional and structural integrity of the tubular and glomerular barrier. miRNAs with a high abundance within the kidney or which are up regulated after an insult are shown in Table . table ft1 table-wrap mode="anchored" t5 Table VII caption a7 MicroRNAs linked to urinary tract and kidney disease miRNA Function/pathway Targets Ref. Bladder cancer miR-129 Signal transduction/protein expression SOX4 GALNT1 ( 44 ) miR-221 Apoptosis TRAIL pathway ( 83 ) miR-1/133a/218 Cytoskeleton LASP1 ( 84 ) miR-19a Apoptosis/mTOR pathway PTEN ( 85 ) miRs-30a-3p/133a/199a Differentiation KRT7 ( 86 ) miR-34a Cell cycle control CDK6 ( 87 ) miR-99a/100 Proliferation FGFR3 ( 88 , 89 ) miR-101 Gene expression EZH2 ( 90 ) miR-125b Apoptosis/proliferation E2F3 ( 91 ) miRs-145/133a Cytoskeleton FSCN1 ( 84 ) miR-145 Signal transduction CBFB PPP3CA CLINT1 ( 92 ) miR-200/205 EMT ZEB 1 and 2 ( 93 , 94 ) miR-200 family EMT ERRFI-1/EMT process ( 95 ) Renal cancer miR-34a Apoptosis Sirt1 ( 87 ) miR-23b Modulation of TGF-ß1 signaling/ apoptosis and hypoxic signaling POX ( 96 ) OncomiR-1 a (Wilms’ tumor) Proliferation response to E2F3 PTEN ( 97 ) miR-200c EMT SIP1 ( 98 ) ZEB2 miR-141 EMT SIP1 ZEB2 Diabetic nephropathy miR-21 Inhibitor of apoptosis/cell proliferation PTEN ( 99 ) miR-23b Modulation of TGF-ß1 signaling/apoptosis and hypoxic signaling POX ( 96 ) miR-30 family Loss in podocyte specific dicer knockout CTGF Xlim1/Lhx1 ( 100 ) miR-192 Collagen synthesis SIP1, ZEB 1 and 2 ( 101 ) miR-216 Modulation of TGF-ß1 signaling YB-1 PTEN ( 102 ) miR-377 Enhanced expression by high glucose in mesangial cells/synthesis of fibronectin PAK1 SOD1/2 ( 103 ) Polycystic kidney disease miR-17 Promotion of proliferation PKD2 ( 104 ) miR-15a Progression cell cycle Cdc25A ( 105 ) Open in a separate window This list is not intended to be exhaustive. a Synonyme miR 17–92 cluster, miR microRNA, PAK1 p21-activated kinase 1, SIP1 Smad-1 interacting protein, SOD superoxide dismutase, TGF-β1 transforming growth factor beta 1, YB-1 Y-box protein-1, PTEN phosphatase and tensin homologue, mTOR mammalian target of rapamycin, EMT epithelial-to-mesenchymal transition Overview of miRNAs Described in Relation to Renal Diseases and/or Damage (Also Shown are the Reexpected Function and Target mRNAs Identified so Far) The expression profile of miRNAs within the healthy kidney has provided a general idea of miRNA constitutive expression and which miRNA serves a specific functional role. ..
Control:Article Title: Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity--An Overview for Applied Toxicology
Article Snippet: .. Experiments with Dicer knockout mice have suggested a critical role of specific miRNAs in orchestrating kidney development and maintaining the functional and structural integrity of the tubular and glomerular barrier. miRNAs with a high abundance within the kidney or which are up regulated after an insult are shown in Table . table ft1 table-wrap mode="anchored" t5 Table VII caption a7 MicroRNAs linked to urinary tract and kidney disease miRNA Function/pathway Targets Ref. Bladder cancer miR-129 Signal transduction/protein expression SOX4 GALNT1 ( 44 ) miR-221 Apoptosis TRAIL pathway ( 83 ) miR-1/133a/218 Cytoskeleton LASP1 ( 84 ) miR-19a Apoptosis/mTOR pathway PTEN ( 85 ) miRs-30a-3p/133a/199a Differentiation KRT7 ( 86 ) miR-34a Cell cycle control CDK6 ( 87 ) miR-99a/100 Proliferation FGFR3 ( 88 , 89 ) miR-101 Gene expression EZH2 ( 90 ) miR-125b Apoptosis/proliferation E2F3 ( 91 ) miRs-145/133a Cytoskeleton FSCN1 ( 84 ) miR-145 Signal transduction CBFB PPP3CA CLINT1 ( 92 ) miR-200/205 EMT ZEB 1 and 2 ( 93 , 94 ) miR-200 family EMT ERRFI-1/EMT process ( 95 ) Renal cancer miR-34a Apoptosis Sirt1 ( 87 ) miR-23b Modulation of TGF-ß1 signaling/ apoptosis and hypoxic signaling POX ( 96 ) OncomiR-1 a (Wilms’ tumor) Proliferation response to E2F3 PTEN ( 97 ) miR-200c EMT SIP1 ( 98 ) ZEB2 miR-141 EMT SIP1 ZEB2 Diabetic nephropathy miR-21 Inhibitor of apoptosis/cell proliferation PTEN ( 99 ) miR-23b Modulation of TGF-ß1 signaling/apoptosis and hypoxic signaling POX ( 96 ) miR-30 family Loss in podocyte specific dicer knockout CTGF Xlim1/Lhx1 ( 100 ) miR-192 Collagen synthesis SIP1, ZEB 1 and 2 ( 101 ) miR-216 Modulation of TGF-ß1 signaling YB-1 PTEN ( 102 ) miR-377 Enhanced expression by high glucose in mesangial cells/synthesis of fibronectin PAK1 SOD1/2 ( 103 ) Polycystic kidney disease miR-17 Promotion of proliferation PKD2 ( 104 ) miR-15a Progression cell cycle Cdc25A ( 105 ) Open in a separate window This list is not intended to be exhaustive. a Synonyme miR 17–92 cluster, miR microRNA, PAK1 p21-activated kinase 1, SIP1 Smad-1 interacting protein, SOD superoxide dismutase, TGF-β1 transforming growth factor beta 1, YB-1 Y-box protein-1, PTEN phosphatase and tensin homologue, mTOR mammalian target of rapamycin, EMT epithelial-to-mesenchymal transition Overview of miRNAs Described in Relation to Renal Diseases and/or Damage (Also Shown are the Reexpected Function and Target mRNAs Identified so Far) The expression profile of miRNAs within the healthy kidney has provided a general idea of miRNA constitutive expression and which miRNA serves a specific functional role. ..
Gene Expression:Article Title: Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity--An Overview for Applied Toxicology
Article Snippet: .. Experiments with Dicer knockout mice have suggested a critical role of specific miRNAs in orchestrating kidney development and maintaining the functional and structural integrity of the tubular and glomerular barrier. miRNAs with a high abundance within the kidney or which are up regulated after an insult are shown in Table . table ft1 table-wrap mode="anchored" t5 Table VII caption a7 MicroRNAs linked to urinary tract and kidney disease miRNA Function/pathway Targets Ref. Bladder cancer miR-129 Signal transduction/protein expression SOX4 GALNT1 ( 44 ) miR-221 Apoptosis TRAIL pathway ( 83 ) miR-1/133a/218 Cytoskeleton LASP1 ( 84 ) miR-19a Apoptosis/mTOR pathway PTEN ( 85 ) miRs-30a-3p/133a/199a Differentiation KRT7 ( 86 ) miR-34a Cell cycle control CDK6 ( 87 ) miR-99a/100 Proliferation FGFR3 ( 88 , 89 ) miR-101 Gene expression EZH2 ( 90 ) miR-125b Apoptosis/proliferation E2F3 ( 91 ) miRs-145/133a Cytoskeleton FSCN1 ( 84 ) miR-145 Signal transduction CBFB PPP3CA CLINT1 ( 92 ) miR-200/205 EMT ZEB 1 and 2 ( 93 , 94 ) miR-200 family EMT ERRFI-1/EMT process ( 95 ) Renal cancer miR-34a Apoptosis Sirt1 ( 87 ) miR-23b Modulation of TGF-ß1 signaling/ apoptosis and hypoxic signaling POX ( 96 ) OncomiR-1 a (Wilms’ tumor) Proliferation response to E2F3 PTEN ( 97 ) miR-200c EMT SIP1 ( 98 ) ZEB2 miR-141 EMT SIP1 ZEB2 Diabetic nephropathy miR-21 Inhibitor of apoptosis/cell proliferation PTEN ( 99 ) miR-23b Modulation of TGF-ß1 signaling/apoptosis and hypoxic signaling POX ( 96 ) miR-30 family Loss in podocyte specific dicer knockout CTGF Xlim1/Lhx1 ( 100 ) miR-192 Collagen synthesis SIP1, ZEB 1 and 2 ( 101 ) miR-216 Modulation of TGF-ß1 signaling YB-1 PTEN ( 102 ) miR-377 Enhanced expression by high glucose in mesangial cells/synthesis of fibronectin PAK1 SOD1/2 ( 103 ) Polycystic kidney disease miR-17 Promotion of proliferation PKD2 ( 104 ) miR-15a Progression cell cycle Cdc25A ( 105 ) Open in a separate window This list is not intended to be exhaustive. a Synonyme miR 17–92 cluster, miR microRNA, PAK1 p21-activated kinase 1, SIP1 Smad-1 interacting protein, SOD superoxide dismutase, TGF-β1 transforming growth factor beta 1, YB-1 Y-box protein-1, PTEN phosphatase and tensin homologue, mTOR mammalian target of rapamycin, EMT epithelial-to-mesenchymal transition Overview of miRNAs Described in Relation to Renal Diseases and/or Damage (Also Shown are the Reexpected Function and Target mRNAs Identified so Far) The expression profile of miRNAs within the healthy kidney has provided a general idea of miRNA constitutive expression and which miRNA serves a specific functional role. ..
Wilms Tumor Assay:Article Title: Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity--An Overview for Applied Toxicology
Article Snippet: .. Experiments with Dicer knockout mice have suggested a critical role of specific miRNAs in orchestrating kidney development and maintaining the functional and structural integrity of the tubular and glomerular barrier. miRNAs with a high abundance within the kidney or which are up regulated after an insult are shown in Table . table ft1 table-wrap mode="anchored" t5 Table VII caption a7 MicroRNAs linked to urinary tract and kidney disease miRNA Function/pathway Targets Ref. Bladder cancer miR-129 Signal transduction/protein expression SOX4 GALNT1 ( 44 ) miR-221 Apoptosis TRAIL pathway ( 83 ) miR-1/133a/218 Cytoskeleton LASP1 ( 84 ) miR-19a Apoptosis/mTOR pathway PTEN ( 85 ) miRs-30a-3p/133a/199a Differentiation KRT7 ( 86 ) miR-34a Cell cycle control CDK6 ( 87 ) miR-99a/100 Proliferation FGFR3 ( 88 , 89 ) miR-101 Gene expression EZH2 ( 90 ) miR-125b Apoptosis/proliferation E2F3 ( 91 ) miRs-145/133a Cytoskeleton FSCN1 ( 84 ) miR-145 Signal transduction CBFB PPP3CA CLINT1 ( 92 ) miR-200/205 EMT ZEB 1 and 2 ( 93 , 94 ) miR-200 family EMT ERRFI-1/EMT process ( 95 ) Renal cancer miR-34a Apoptosis Sirt1 ( 87 ) miR-23b Modulation of TGF-ß1 signaling/ apoptosis and hypoxic signaling POX ( 96 ) OncomiR-1 a (Wilms’ tumor) Proliferation response to E2F3 PTEN ( 97 ) miR-200c EMT SIP1 ( 98 ) ZEB2 miR-141 EMT SIP1 ZEB2 Diabetic nephropathy miR-21 Inhibitor of apoptosis/cell proliferation PTEN ( 99 ) miR-23b Modulation of TGF-ß1 signaling/apoptosis and hypoxic signaling POX ( 96 ) miR-30 family Loss in podocyte specific dicer knockout CTGF Xlim1/Lhx1 ( 100 ) miR-192 Collagen synthesis SIP1, ZEB 1 and 2 ( 101 ) miR-216 Modulation of TGF-ß1 signaling YB-1 PTEN ( 102 ) miR-377 Enhanced expression by high glucose in mesangial cells/synthesis of fibronectin PAK1 SOD1/2 ( 103 ) Polycystic kidney disease miR-17 Promotion of proliferation PKD2 ( 104 ) miR-15a Progression cell cycle Cdc25A ( 105 ) Open in a separate window This list is not intended to be exhaustive. a Synonyme miR 17–92 cluster, miR microRNA, PAK1 p21-activated kinase 1, SIP1 Smad-1 interacting protein, SOD superoxide dismutase, TGF-β1 transforming growth factor beta 1, YB-1 Y-box protein-1, PTEN phosphatase and tensin homologue, mTOR mammalian target of rapamycin, EMT epithelial-to-mesenchymal transition Overview of miRNAs Described in Relation to Renal Diseases and/or Damage (Also Shown are the Reexpected Function and Target mRNAs Identified so Far) The expression profile of miRNAs within the healthy kidney has provided a general idea of miRNA constitutive expression and which miRNA serves a specific functional role. ..
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